PATHOMORPHOLOGY OF THE INTEGRAL CONNECTION OF THE ADRENAL GLANDS AND THYMUSIS IN RDS SYNDROME IN NEWBORN INFANTS

Abstract

This study investigates the pathomorphological interrelationship between the adrenal glands and thymus in newborns diagnosed with Respiratory Distress Syndrome (RDS). RDS is a critical neonatal condition primarily affecting lung function, but it also induces systemic changes impacting multiple organs. The research focuses on examining structural and functional alterations in the adrenal cortex and thymic tissue, revealing how these organs respond integrally to the stress and hypoxia associated with RDS. Findings indicate adrenal hyperplasia and thymic involution, reflecting a complex neuroendocrine-immune interaction that compromises neonatal adaptation and immunity. Understanding these changes provides crucial insights into the systemic nature of RDS and suggests the necessity for comprehensive therapeutic approaches that address endocrine and immune dysfunction alongside respiratory management. This work contributes to improving clinical outcomes by highlighting potential targets for intervention in neonatal care.