Ключевые слова
Аннотация
Pulmonary gas exchange is a fundamental physiological process essential for maintaining adequate oxygen delivery and carbon dioxide removal in the human body.
Impairments in gas exchange are associated with a variety of respiratory disorders, including chronic obstructive pulmonary disease, pneumonia, asthma, and interstitial lung diseases. Traditional diagnostic methods often provide only indirect or macro-level assessments of pulmonary function, limiting early detection and precise evaluation of pathophysiological changes. This study focuses on the biophysical simulation of pulmonary gas exchange, employing mathematical modeling to reproduce alveolar-capillary diffusion, ventilation-perfusion distribution, and gas transport dynamics. The integration of clinical data, including arterial blood gas analysis, spirometry, and imaging results, into simulation models enhances diagnostic accuracy and enables individualized evaluation of pulmonary function. The findings demonstrate that biophysical simulation is an effective tool for early detection of functional impairments, optimization of treatment strategies, and prediction of disease progression. This approach has significant potential for integration into precision medicine and advanced digital diagnostics.
Библиографические ссылки
West, J.B. (2012). Respiratory Physiology: The Essentials. 9th Edition. Wolters Kluwer Health, pp. 45–92.
Levitzky, M.G. (2013). Pulmonary Physiology. 8th Edition. McGraw-Hill Education, pp. 105–160.
Wagner, P.D. (2015). “Gas Exchange in the Lungs: Physiological and Clinical Perspectives.” Comprehensive Physiology, 5(2), pp. 827–895.
Hughes, J.M.B., & Pride, N.B. (2016). Clinical Respiratory Medicine. 5th Edition. Elsevier, pp. 210–255.
Rees, S.E., Kearney, M., & Andreassen, S. (2006). “Mathematical Modeling of Pulmonary Gas Exchange.” Journal of Applied Physiology, 101(6), pp. 1692–1702.
Bates, J.H.T., & Irvin, C.G. (2011). “Time-Dependent Modeling of Alveolar Ventilation and Perfusion.” Respiratory Physiology & Neurobiology, 177(1), pp. 50–60.
Cereda, M., & Farina, D. (2017). “Computational Approaches in Pulmonary Function Assessment.” Frontiers in Physiology, 8: 891.
West, J.B., & Luks, A.M. (2019). West’s Respiratory Physiology: The Essentials. 10th Edition. Wolters Kluwer, pp. 65–120.