ON THE ROLE OF LIPID METABOLISM DISORDERS IN THE DEVELOPMENT OF KIDNEY DAMAGE IN METABOLIC SYNDROME

Аннотация

Metabolic syndrome is one of the most significant medical and social problems of modern healthcare due to its high prevalence and association with cardiovascular diseases and chronic kidney disease. Disorders of lipid metabolism play a key role in the pathogenesis of renal damage in patients with metabolic syndrome, contributing to glomerular hyperfiltration, endothelial dysfunction, and progressive decline of renal function. The aim of this study was to assess the role of lipid metabolism disorders in the development of kidney damage in patients with metabolic syndrome. The study included 95 patients aged 19 to 77 years who underwent anthropometric, biochemical, and functional assessment of renal function. Lipid profile parameters and glomerular filtration rate calculated by the MDRD formula were analyzed depending on body mass index. The results demonstrated that dyslipidemia in patients with metabolic syndrome is characterized by elevated levels of triglycerides, total cholesterol, and low-density lipoproteins, accompanied by a decrease in high-density lipoproteins. A significant correlation was identified between lipid spectrum disturbances and markers of renal dysfunction, including elevated serum creatinine levels and reduced glomerular filtration rate.

These findings indicate that lipid metabolism disorders play an important role in the development of renal impairment in metabolic syndrome and highlight the necessity of early detection of kidney dysfunction using estimated glomerular filtration rate even in patients with normal creatinine levels.