PHYTOCHEMICAL TARGETING OF THE MYCOBACTERIAL Rv2349c (PlcC) VIRULENCE CASCADE: STRUCTURAL MECHANISMS OF PHAGOSOMAL STABILIZATION AND MACROPHAGE AUTOPHAGIC RESCUE IN DRUG-RESISTANT TUBERCULOSIS
Том 3 № 10 (2026), Статьи
Том 3 № 10 (2026)

PHYTOCHEMICAL TARGETING OF THE MYCOBACTERIAL Rv2349c (PlcC) VIRULENCE CASCADE: STRUCTURAL MECHANISMS OF PHAGOSOMAL STABILIZATION AND MACROPHAGE AUTOPHAGIC RESCUE IN DRUG-RESISTANT TUBERCULOSIS

Статьи
Опубликован 2026-10-04
  • Abdulbakiy Khushnudbekov
Abdulbakiy Khushnudbekov
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Ключевые слова

Mycobacterium tuberculosis, Rv2349c gene, Phospholipase C (PlcC), Plant Metabolites,

Аннотация

Tuberculosis (TB), driven by virulent Mycobacterium tuberculosis (M. tuberculosis) strains, remains a primary cause of global infectious mortality, acutely aggravated by the widespread occurrence of multidrug-resistant (MDR-TB) and extensively drug-resistant (XDR-TB) phenotypes.

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Библиографические ссылки

Johansen, M. D., et al. (2021). Mycobacterial phospholipases C: Structure, function, and roles in pathogenesis and immune evasion. Frontiers in Immunology, 12, 663201.