ORIGIN AND MODERN CLINICAL DIAGNOSIS OF INFILTRATIVE HEART DISEASES
Том 2 № 2 (2025), Articles
Том 2 № 2 (2025)

ORIGIN AND MODERN CLINICAL DIAGNOSIS OF INFILTRATIVE HEART DISEASES

Articles
Опубликован 2025-02-18
  • Davlat Ergashev
  • Mehroj Xolmatov
  • Husan Boltayev
  • Akmal Mardonqulov
  • Asomiddin Yavg'ashev
Davlat Ergashev
Mehroj Xolmatov
Husan Boltayev
Akmal Mardonqulov
Asomiddin Yavg'ashev
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Ключевые слова

The prognosis of cardiac amyloidosis is very unfavorable. However, in recent years, certain progress has been made not only in diagnostics, but also in the development of drug therapy for cardiac amyloidosis, so that experts from the Working Group on Myocardial and Pericardial Diseases of the European Society of Cardiology have developed a consensus document on the diagnosis and treatment of cardiac amyloidosis [1].

Аннотация

To date, nine amyloidogenic proteins have been identified that can accumulate in the myocardium and cause cardiac amyloidosis. Three of them are common: serum amyloid A (AA amyloidosis, a consequence of chronic inflammation and infectious diseases), immunoglobulin light chains (AL amyloidosis, a consequence of monoclonal gammopathy), and transthyretin (two variants of transthyretin - ATTR amyloidosis: ATTRv amyloidosis, here ATTRv amyloidosis is associated with a non-hereditary type of transthyretin amyloidosis).

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