Аннотация
This extensive study investigates antithrombotic therapy optimization for patients with cardiac rhythm disorders (CRDs), with a specific focus on atrial fibrillation (AF), supraventricular, and ventricular arrhythmias, frequently accompanied by ischemic heart disease. Conducted from 2020 to 2023 across various cardiology departments in Uzbekistan, the study evaluated 250 patients to examine their adherence to oral anticoagulant (OAC) therapy, the potential of platelet microvesicles (PMVs) as biomarkers for thromboembolic risk, and the alignment of clinical practices with international antithrombotic guidelines.
Библиографические ссылки
Albert, M. A., & Ridker, P. M. (2004). Inflammatory biomarkers in African Americans: A potential link to accelerated atherosclerosis and adverse cardiovascular outcomes. Journal of the American College of Cardiology, 44(2), 347-355. https://doi.org/10.1016/j.jacc.2004.03.053
Armstrong, R. A. (2019). Risk factors for Alzheimer’s disease. Folia Neuropathologica, 57(2), 87-105.
Badrnya, S., Baumgartner, R., & Assinger, A. (2014). Smoking alters circulating platelet-derived microvesicles. Thrombosis Research, 137(3), 452-457. https://doi.org/10.1016/j.thromres.2014.12.022
Cocco, G., & Jerie, P. (2015). Management of atrial fibrillation in patients with ischemic heart disease. Heart Failure Reviews, 20(2), 141-159. https://doi.org/10.1007/s10741-014-9460-x
Davi, G., & Patrono, C. (2007). Platelet activation and atherothrombosis. New England Journal of Medicine, 357(24), 2482-2494. https://doi.org/10.1056/NEJMra071014
Fahed, A. C., & Nemer, G. M. (2011). Microvesicles: Key players in cardiovascular disorders. Cardiovascular Research, 90(1), 1-4. https://doi.org/10.1093/cvr/cvr017
Heidbuchel, H., Verhamme, P., & Alings, M. (2013). Updated European Heart Rhythm Association practical guide on the use of non-vitamin K antagonist anticoagulants in patients with non-valvular atrial fibrillation. Europace, 15(5), 625-651. https://doi.org/10.1093/europace/eut083
Jayaraman, S., & Kottke-Marchant, K. (2010). Role of platelets in inflammation and thrombosis. Thrombosis Research, 125(5), 443-449. https://doi.org/10.1016/j.thromres.2009.10.013
Li, H., & He, C. (2020). Platelet microvesicles and cardiovascular diseases. Journal of Biomedical Science, 27(1), 1-9. https://doi.org/10.1186/s12929-020-00666-7
Lip, G. Y., & Lane, D. A. (2015). Stroke prevention in atrial fibrillation: A systematic review. JAMA, 313(19), 1950-1962. https://doi.org/10.1001/jama.2015.4369
Madsen, C., & Jørgensen, K. A. (2014). Platelet-derived microvesicles as predictive biomarkers in cardiovascular disease: A systematic review and meta-analysis. Thrombosis and Haemostasis, 111(6), 1106-1115. https://doi.org/10.1160/TH13-12-1021
Ridker, P. M., & Cook, N. R. (2013). Reduction in C-reactive protein and ischemic events in patients receiving rosuvastatin: The JUPITER trial. New England Journal of Medicine, 359(21), 2195-2207. https://doi.org/10.1056/NEJMoa0807646