OPTIMIZATION OF DIAGNOSTIC METHODS AND OUTCOME PREDICTION IN YOUNG ADULTS WITH TRAUMATIC BRAIN INJURY
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Ключевые слова

traumatic brain injury, young adults, diagnostics, prognosis, biomarkers, S100B, neuron-specific enolase, outcome prediction.

Аннотация

The study aimed to optimize diagnostic methods and predict outcomes in young adults with traumatic brain injury (TBI). Data from 100 patients admitted to neurosurgery and intensive care units were analyzed, including clinical, neurological, and laboratory parameters. Serum biomarkers, such as S100B and neuron-specific enolase (NSE), were measured to assess the severity of brain tissue and meningeal damage. Patients with higher biomarker levels had more severe injuries and longer recovery, while integration of these markers into a diagnostic-prognostic model improved accuracy in predicting unfavorable outcomes. The proposed algorithm allowed effective patient stratification and individualized management. The findings indicate that combining clinical evaluation with laboratory biomarkers enhances diagnostic precision and can improve treatment results in young adults with TBI.

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Библиографические ссылки

Zarei H., Roshdi Dizaji S., Toloui A., Yousefifard M., Esmaeili A. Diagnostic and prognostic values of S100B versus neuron specific enolase for traumatic brain injury: a systematic review and meta analysis // Archives of Academic Emergency Medicine. — 2024. — Vol. 12, No. 1. — Article e29. — DOI: 10.22037/aaem.v12i1.2222.

Sutrisno W.A., Airlangga P.S., Wungu C.D.K., Kriswidyatomo P., Semedi B.P., Mahmudah M. The role of neuron specific enolase, S100B, glial fibrillary acidic protein and myelin basic protein as prognostic and survival values in traumatic brain injury: systematic review and meta analysis // Pharmacognosy Journal. — 2024. — Vol. 16, No. 2. — P. 478–484.

Huang L., et al. Predictive value of nervous cell injury biomarkers in moderate-to-severe traumatic brain injury: a network meta analysis // [journal name — as in source]. — 2024.