Keywords
Abstract
Ushbu maqola xromosoma nazariyasining molekulyar genetika uchun konseptual va amaliy ahamiyatini yoritadi. Genlarning xromosomalardagi joylashuvi, genetik informatsiyaning DNK va RNK orqali uzatilishi, rekombinatsiya va fenotipik ifodaga ta’sir qiluvchi mexanizmlar qisqacha tahlil qilinadi. Trisomiya, monosomiya va struktural anomaliyalar kabi xromosoma buzilishlarining irsiy kasalliklar bilan bog‘liqligi ko‘rsatib o‘tiladi. Shuningdek, gene linkage, epistaz va evolyutsion jarayonlardagi xromosoma o‘zaro ta’sirlari umumlashtiriladi. Mitoz va meyozda genetik materialning taqsimlanishi hamda gen kartografiyasi va molekulyar markerlar kabi zamonaviy genetika usullarining ahamiyati qisqa bayon etiladi. Maqola klinik genetika, evolyutsion biologiya va biotexnologiyadagi qo‘llanilishlar doirasida xromosoma nazariyasining umumiy ilmiy-amaliy qiymatini baholaydi.
References
Griffiths, A. J. F., Wessler, S. R., Lewontin, R. C., & Carroll, S. B. Introduction to Genetic Analysis. 12th Edition. W. H. Freeman, 2020. (https://www.macmillanlearning.com/college/us/product/Introduction-to-Genetic-Analysis/p/1319218841)
Brown, T. A. Genomes 4. Garland Science, 2018. (https://www.routledge.com/Genomes-4th-Edition/Brown/p/book/9780815345085)
Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raff, M., Roberts, K., & Walter, P. Molecular Biology of the Cell. 6th Edition. Garland Science, 2015. (https://www.garlandscience.com/molecular-biology-of-the-cell-6e)
Strachan, T., & Read, A. Human Molecular Genetics. 5th Edition. Garland Science, 2018. (https://www.garlandscience.com/human-molecular-genetics-5e)
Lodish, H., Berk, A., Kaiser, C. A., Krieger, M., Bretscher, A., Ploegh, H., & Matsudaira, P. Molecular Cell Biology. 8th Edition. W. H. Freeman, 2021. (https://www.whfreeman.com/molecular-cell-biology-8e)
Hartwell, L., Hood, L., Goldberg, M., Reynolds, A., Silver, L., & Veres, R. Genetics: From Genes to Genomes. 6th Edition. McGraw-Hill Education, 2017. (https://www.mheducation.com/highered/product/genetics-genes-genomes-hartwell-hodder/M9781259254048.html)
Watson, J. D., Baker, T. A., Bell, S. P., Gann, A., Levine, M., & Losick, R. Molecular Biology of the Gene. 7th Edition. Pearson, 2014. (https://www.pearson.com/store/p/molecular-biology-of-the-gene/P100000744065)
Cooper, G. M., & Hausman, R. E. The Cell: A Molecular Approach. 8th Edition. ASM Press, 2019. (https://www.asmscience.org/content/book/10.1128/9781555819584)