Keywords
Abstract
Polyendocrine Metabolic Ovarian Syndrome (PMOS) is an emerging clinical construct that encompasses the convergence of multiple endocrine dysregulations principally hyperandrogenism, insulin resistance, hypothyroidism, and hyperprolactinemia manifesting with ovarian dysfunction, metabolic disturbance, and reproductive impairment.
Unlike classical Polycystic Ovary Syndrome (PCOS), PMOS integrates simultaneous or sequential dysfunction across the thyroid, adrenal, and gonadal axes, creating a complex, overlapping endocrine phenotype that challenges conventional diagnostic algorithms and single axis therapeutic protocols.
References
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