SYNTHESIS OF NEW BIS-1,2,3-TRIAZOLE DERIVATIVES BASED ON DIPROPARGYL ADIPATE

Abstract

This study presents the synthesis of new bis-1H-1,2,3-triazole derivatives based on dipropargyl adipate. The target compounds were synthesized according to the principles of click chemistry via a copper(I)-catalyzed azide–alkyne cycloaddition (CuAAC) between aromatic azides and terminal alkyne fragments. p-Azidotoluene and p-azidoanisole were employed as the azide components. The selected synthetic approach is characterized by high product yields, relatively simple reaction conditions, and the high regioselectivity typical of CuAAC processes.