Abstract
Climacteric syndrome (CS) is a pathological condition characteristic of most women during the period of physiological decline in ovarian function. The most common early symptoms of menopause include vasomotor symptoms, including hot flashes and night sweats, and emotional disturbances (depressive states, sleep disorders, etc.), which are observed in approximately 75% of perimenopausal women and can last for 10 years or more [1-5].
It is currently believed that immune dysregulation, particularly changes in cytokine balance, may play an important role in the pathogenesis of early menopause [6, 7]. Vitamin D metabolism disorders may also be involved in the pathogenesis of KS. Thus, a link between 25(OH)D deficiency and vasomotor symptoms has been identified
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