SPECIFIC PROPERTIES OF THE DRUG METRONIDAZOLE, GALAVIT AND ITS EFFECT ON INFECTION

Abstract

Inflammatory diseases have an extremely unfavourable impact on the reproductive function of women, causing chronic pelvic pain syndrome (24%), infertility (40%), pregnancy failure (45%), ectopic pregnancy (3%) [5, 6]. The main trigger mechanism in the development of inflammation is microbial invasion (microbial factor). Analysis of the results of numerous bacteriological studies in gynaecology performed over the last 50 years revealed a change in the causative agents of pelvic inflammatory diseases. In the 40s-60s of the XX century the leading place was occupied by streptococcus (31.4%); in the 60s-70s - by staphylococcus (54.5%). Since the 1980s, most researchers have been unanimous in the opinion that the leading initiator of UTIs are associations of non-spore-forming Gram-negative (Bacteroides, Prevotella, Fusobacteria) and Gram-positive anaerobic microorganisms (peptostreptococci and clostridia), aerobic Gram-negative (Escherichia coli, Klebsiella, Proteus, Enterobacteriaceae) and less frequently Gram-positive microbial flora (Streptococcus, Enterococcus, Staphylococcus aureus).

Almost all microorganisms present in the vagina (with the exception of lacto- and bifidobacteria) can take part in the inflammatory process. Since the 80-90s of the XX century, great importance in the genesis of STIs has been given to sexually transmitted infections (STIs) (chlamydia, mycoplasmosis, ureaplasmosis, viral infection, candidiasis), 50-70% of pelvic organ diseases are caused by chlamydia and ureaplasmas. The ways in which infection affects the female reproductive system are manifold.