COMPARISON OF SIDERAL® AND STANDARD ORAL IRON THERAPIES IN CHILDREN WITH CHRONIC KIDNEY DISEASE: EFFICACY AND TOLERABILITY STUDY
PDF

Keywords

Children, Chronic Kidney Disease, Anemia, Iron Deficiency, Sideral®, Sucrosomial® Iron.

Abstract

The study compares SiderAL® (Sucrosomial® Iron) and traditional ferrous sulfate in treating anemia in children with chronic kidney disease (CKD). Sixty children aged 5–15 years with CKD stages II–IV and iron deficiency anemia participated in a 12-week randomized study. Results showed that both therapies improved hemoglobin and serum iron levels, but SiderAL® produced significantly better results and fewer gastrointestinal side effects (6.7% vs. 26.7%). Treatment adherence was also higher with SiderAL® (93.3%). Thus, SiderAL® proved to be more effective and better tolerated than standard iron preparations for managing anemia in children with CKD.

PDF

References

Andrushchak E.V., Gerasimova N.A., Kuznetsova S.M. Anemia in children with chronic kidney disease: pathogenesis, diagnosis and approaches to therapy. Nephrology and Dialysis, 2021; 23(4): 312–320.

Abaev Yu.K., Pshenichnaya N.Yu. Iron metabolism in children with chronic kidney disease. Pediatrics, 2020; 99(3): 45–51.

Hörl W.H. Iron therapy for renal anemia: how much needed, how much harmful? Pediatric Nephrology, 2020; 35(12): 2145–2156.

Ricci F., et al. Sucrosomial® iron supplementation in pediatric patients with iron deficiency anemia: efficacy and tolerability compared with ferrous sulfate. Eur. J. Pediatr., 2021; 180: 1891–1898.

Locatelli F., et al. KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. Kidney Int. Suppl., 2021; 11(1): 1–135.

Vaucher P., et al. Effect of oral sucrosomial iron on hemoglobin and iron stores in iron deficiency anemia. Haematologica, 2020; 105(10): 2502–2509.

Ganz T., Nemeth E. Hepcidin and iron homeostasis in health and disease. Annu. Rev. Med., 2021; 72: 343–358.

Pasricha S.-R., et al. Iron deficiency. The Lancet, 2021; 397(10270): 233–248.

Ganina A.V., Fedorova T.V. Modern approaches to oral correction of iron deficiency anemia in children: advantages of sucrosomial iron. Current Pediatrics, 2022; 21(5): 60–65.

Strokova T.V., Novikova E.A. The role of inflammation and hepcidin in the formation of anemia of chronic disease in children. Russian Bulletin of Perinatology and Pediatrics, 2020; 65(6): 87–92.

Zavaleta N., Astete-Robilliard L. Efficacy and safety of iron supplementation in children with chronic diseases: a review. Front. Pediatr., 2022; 10: 889743.

Macdougall I.C., et al. Iron management in chronic kidney disease: KDIGO Controversies Conference. Kidney Int., 2019; 96: 37–47.

Ashurova N.Sh., Ibragimova D.N., Botirova D.T., Farmonova A.S. Sucrosomial iron in the treatment of anemia in children with chronic kidney disease: current approaches and prospects. Journal Vestnik Vracha, 2025; 2(119): 100–102.

Ashurova N.Sh., Muradova M.D. A modern view of anemia in children with chronic kidney disease. Journal Vestnik Vracha, 2024; 4(116): 106–111.

Ashurova N.Sh. Dynamics of hemoregulation indices after treatment of absolute anemia in children with chronic kidney disease. ISJ Theoretical & Applied Science, 2024; 10(138): 151–156.

Shuxratovna A.N. Evaluation of hemodynamic parameters after treatment of functional anemia in children with chronic kidney disease. Frontline Medical Sciences and Pharmaceutical Journal, 2024; 4(10): 38–47.

Ashurova N.Sh., Mukhamadiev N.Q. Assessment of hemodynamic parameters by type of anemia in children with chronic kidney disease. Central Asian Journal of Medical and Natural Science, 2024; 5(4): 230–238.

Ashurova N.Sh. Comparative analysis of iron metabolism parameters in children with chronic kidney disease with and without anemia. American Journal of Medicine and Medical Sciences, 2025; 15(7): 2114–2117.