Keywords
Abstract
This study examines the clinical significance of Human Papillomavirus infection in women of reproductive age and evaluates modern approaches to its prevention. The study included 40 women who underwent clinical, laboratory, and screening assessment.
Particular attention was paid to the clinical manifestations of infection, identification of high-risk viral types, screening findings, concomitant genital infections, and preventive factors.
The results demonstrated that Human Papillomavirus infection may occur both with clinical manifestations and in an asymptomatic form. The findings emphasize the importance of early laboratory diagnosis and regular screening for timely identification of clinically significant changes. Vaccination, systematic screening, individual risk assessment, health education, and appropriate clinical follow-up are considered important components of comprehensive prevention.
References
Arbyn M., Weiderpass E., Bruni L. et al. Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis // The Lancet Global Health. - 2020. - Vol. 8, No. 2. - P. 191–203.
Sung H., Ferlay J., Siegel R.L. et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries // CA: A Cancer Journal for Clinicians. - 2021. - Vol. 71, No. 3. - P. 209–249.
Schiffman M., Doorbar J., Wentzensen N. et al. Carcinogenic human papillomavirus infection // Nature Reviews Disease Primers. - 2016. - Vol. 2..
Doorbar J., Egawa N., Griffin H. et al. Human papillomavirus molecular biology and disease association // Reviews in Medical Virology. - 2015. - Vol. 25, Suppl. 1. - P. 2–23.
Cohen P.A., Jhingran A., Oaknin A., Denny L. Cervical cancer // The Lancet. - 2019. - Vol. 393, No. 10167. - P. 169–182.
de Martel C., Plummer M., Vignat J., Franceschi S. Worldwide burden of cancer attributable to HPV by site, country and HPV type // International Journal of Cancer. - 2017. - Vol. 141, No. 4. - P. 664–670.