Ключевые слова
Аннотация
Revmatoid artrit - hozirgi vaqtda bu kasallik nafaqat sog'liqni saqlash tizimining, balki jahon hamjamiyatining ijtimoiy-iqtisodiy muammolaridan biriligicha qolmoqda.
Misol uchun dunyo bo'ylab 18 million inson revmatoid artrit bilan kasallangan. Birgina Buyuk Britaniyada har yili Revmatoid artritning 24 500 dan ortiq yangi holatlari aniqlanadi. 2029 - yilga borib yangi tashxis qo'yilgan holatlar 25 400 dan ortishi kutilmoqda. 2000-2019 yillar oralig‘ida kasallanish soni 100 000 kishiga 58.4 dan 94,0 gacha ko‘tarilgan.
Библиографические ссылки
Emélie Braschi, Kam Shojania, G Michael Allan. Anti-CCP: a truly helpful rheumatoid arthritis test? Clinical summary: specificity ~96%, sensitivity 53–71%; predicts joint erosion.
Avouac J, Gossec L, Dougados M. Diagnostic and predictive value of anti-cyclic citrullinated protein antibodies in rheumatoid arthritis: a systematic literature review. Ann Rheum Dis. 2006. Systematic review confirming diagnostic and predictive value of anti-CCP.
Qingmei Cao et al. Clinical significance of combined anti-CCP antibody and RF assays in rheumatoid arthritis diagnosis. Arch Rheumatol. 2015;87.1 sensitivity of combo vs single assays (87.1% vs 70%, 77.1%).
Sun J, Zhang Y, Liu L, Liu G. Diagnostic accuracy of combined tests of anti-cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis: a meta-analysis. Clin Exp Rheumatol. 2014. Combo improves true positivity probability.
Emélie Braschi et al — already includes prognostic info; (same as 1).
J Avouac et al. Diagnostic and predictive value of anti-CCP (covers both) .
Mjaavatten MD et al. The likelihood of persistent arthritis increases with the level of anti-CCP or RF. Arthritis Res. 2010. High levels predict aggressive course .
N Bizzaro et al. Anti-CCP antibody titer predicts time to RA diagnosis and risk in undifferentiated arthritis. Arthritis Res Ther. 2013. Higher titers = shorter time to diagnosis; prognostic value.
N Kroot et al. The prognostic value of anti-CCP antibody in early RA patients. Arthritis Rheum. 2000. Presents early presence of anti-CCP in ~70% .
TB Niewold et al. Anti-CCP antibody testing as a diagnostic and prognostic tool. QJM. 2007. High specificity, early appearance, prognostic utility.