PREECLAMPSIA BEYOND PREGNANCY: LONG-TERM CONSEQUENCES FOR MOTHER AND CHILD

Аннотация

Preeclampsia is a complex hypertensive disorder of pregnancy with systemic manifestations that extend far beyond delivery. Once considered a transient obstetric complication, preeclampsia is now recognized as a powerful predictor of future cardiovascular, renal, metabolic, and neurodevelopmental disease in both mother and offspring. Large-scale cohort studies and meta-analyses demonstrate that women with a history of preeclampsia have a two- to fourfold increased risk of chronic hypertension, ischemic heart disease, stroke, heart failure, and end-stage renal disease later in life [1–4]. Similarly, offspring exposed to preeclampsia in utero exhibit increased susceptibility to hypertension, metabolic syndrome, and neurodevelopmental disorders, supporting the developmental origins of health and disease hypothesis [5–7]. This review integrates epidemiologic, mechanistic, and clinical evidence to elucidate the long-term consequences of preeclampsia and proposes a framework for lifelong surveillance and prevention strategies for affected mothers and children.