Ключевые слова
Аннотация
P-glikoprotein (P-gp, ABCB1) ko‘krak saratoni hujayralarida kimyoterapiyaga chidamlilikni shakllantiruvchi asosiy ATP-bog‘liq efflyuks transporteri hisoblanadi. Ushbu maqolada P-gp ekspressiyasi, uning hujayra yashovchanligi va sitotoksiklikka ta’siri Western blotting, LDH va cell viability usullari asosida tahlil qilindi.
Olingan natijalar P-gp yuqori ekspressiyasi dorilarining hujayra ichida to‘planishini kamaytirib, kimyoterapiya samaradorligini pasaytirishini ko‘rsatadi.
Библиографические ссылки
Gottesman MM. Multidrug resistance in cancer. Nat Rev Cancer.
https://pubmed.ncbi.nlm.nih.gov/12407403/
Robey RW et al. P-glycoprotein and cancer drug resistance. Nat Rev Cancer.
https://pubmed.ncbi.nlm.nih.gov/39245345/
Leonessa F, Clarke R. ATP-binding cassette transporters and breast cancer. Endocr Relat Cancer.
https://pubmed.ncbi.nlm.nih.gov/16360717/
Kathawala RJ et al. Strategies to overcome P-gp mediated resistance. Drug Resist Updat.