Keywords
Abstract
Circulatory failure is a critical condition characterized by the inability of the cardiovascular system to maintain adequate tissue perfusion and oxygen delivery. This leads to cellular hypoxia, organ dysfunction, and if untreated, multiple organ failure and death. The paper discusses the pathophysiology, classification, clinical manifestations, diagnostic approaches, and treatment strategies related to circulatory failure. It highlights the body’s compensatory mechanisms and their dual role in initially preserving function but potentially causing further harm if prolonged. Early diagnosis and tailored therapeutic interventions are emphasized as essential to improve patient outcomes. Understanding the underlying cardiovascular changes and systemic responses is crucial for effective management of circulatory failure and reducing associated morbidity and mortality.
References
Guyton, A.C., & Hall, J.E. (2016). Textbook of Medical Physiology (13th Edition). Elsevier Saunders.
Kumar, V., Abbas, A.K., Aster, J.C. (2018). Robbins Basic Pathology (10th Edition). Elsevier.
Braunwald, E. (2019). Heart Disease: A Textbook of Cardiovascular Medicine (11th Edition). Elsevier.
Vincent, J.L., & De Backer, D. (2013). Circulatory shock. The New England Journal of Medicine, 369(18), 1726-1734.
Levy, B., & Collin, S. (2018). Pathophysiology of shock. Annals of Intensive Care, 8(1), 13.
Porth, C.M., & Matfin, G. (2014). Pathophysiology: Concepts of Altered Health States (9th Edition). Wolters Kluwer.
Cecconi, M., De Backer, D., Antonelli, M., et al. (2014). Consensus on circulatory shock and hemodynamic monitoring. Intensive Care Medicine, 40(12), 1795-1815.