Keywords
Abstract
Chronic academic stress is increasingly recognized as a significant neurobiological risk factor among medical students. Persistent activation of the hypothalamic–pituitary–adrenal (HPA) axis leads to prolonged cortisol elevation, which has been associated with hippocampal atrophy, impaired synaptic plasticity, and reduced executive functioning.
According to global meta-analyses, approximately 52–67% of medical students report high perceived stress, and 27–35% demonstrate clinically significant symptoms of anxiety or depression. This study analyzes the neurobiological mechanisms underlying stress-induced cognitive impairment and evaluates measurable cognitive outcomes among medical students.
The findings confirm a statistically significant association between chronic stress and decreased working memory, attention span, and decision-making capacity. Early institutional interventions are essential to protect neurocognitive health and ensure sustainable professional competence.
References
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